We report the first record of Portulaca amilis in Tennessee. A native of South America, P. amilis is a weedy plant that has been introduced to and naturalized in the southeastern United States. Previously this species has only been reported from the Atlantic Coastal Plain and Piedmont. This suggests a range expansion either west over the Appalachian Mountains from the Carolinas, or north from Georgia, Alabama, or Mississippi into the Ridge and Valley region of east Tennessee.