A floristic survey of Cunningham Brake, a cypress-gum swamp located in Kisatchie National Forest approximately 32 kilometers south of Natchitoches, Louisiana, was conducted from February, 1977, to June, 1978. The study area is characterized by six distinct habitats: 1) cypress-gum swamp; 2) lowland hardwoods; 3) open sand bars and edges of Kisatchie Bayou; 4) seepage areas; 5) wet, open areas; and 6) disturbed areas. The annotated list of taxa includes 81 families, 213 genera, and 313 species.