The vascular flora of the Chickasaw National Recreation Area, Murray County, Oklahoma, was inventoried. The study area is located in the Arbuckle Mountains physiographic region of Oklahoma. The geology of this region is composed of limestone and conglomerate rocks which is unique to the predominantly sandstone surface geology of central Oklahoma. A total of 582 taxa of vascular plants in 358 genera and 104 families was verified in the present study, resulting in a list of 717 taxa when combined with results from previous studies. No federally listed or endangered species were encountered, ten species tracked by the Oklahoma Natural Heritage Inventory were present. Comparisons to previous floristic surveys were made and descriptions of the major vegetation associations were provided.